PI4-Kinase II alpha (PI4KIIa), active

Produktübersicht

• Artikelname: PI4-Kinase II alpha (PI4KIIa), active
• Artikelnummer: ECH-P21-10G
• Hersteller Artikelnummer: P21-10G
• Alternativnummer: ECH-P21-10G-10UG, ECH-P21-10G-5UG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

Full-length recombinant human PI4KIIA was co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Enzyme obtained from SignalChem. Molecular weight: ~79 kDa Sequence: Full length Species: Human Tag: GST tag Purity: >90 % (request TDS for lot specific information) Specific Activity: >30 nmol/min/mg (request TDS for lot specific information) Expression System: Sf9 insect cells using baculovirus Genebank Number: NM_018425 Applications: PI 4-Kinase assay, western blot. Formulation: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. Storage and stability: Store product at -70C. Stable up to one year.

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Product Description PI4KIIA or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KIIA phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4KIIA is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4KIIA generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes. PI4KIIA is also required for Wnt to regulate LRP6 phosphorylation.

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Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Antibodies & Proteins. Related: Enzyme, Kinase, PI4K. Ship 1 : Shipping Temp. Ship 2: Dry Ice