Biotinylated Anti-PtdIns(3,4,5)P3 IgM

Produktübersicht

• Artikelname: Biotinylated Anti-PtdIns(3,4,5)P3 IgM
• Artikelnummer: ECH-Z-B345
• Hersteller Artikelnummer: Z-B345
• Alternativnummer: ECH-Z-B345-10UG, ECH-Z-B345-50UG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

Purified Anti-PtdIns(3,4,5)P3 monoclonal antibody conjugated with biotin. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.