Purified Anti-PtdIns(3,4,5)P3 IgM

Produktübersicht

• Artikelname: Purified Anti-PtdIns(3,4,5)P3 IgM
• Artikelnummer: ECH-Z-P345
• Hersteller Artikelnummer: Z-P345
• Alternativnummer: ECH-Z-P345-10UG, ECH-Z-P345-250UG, ECH-Z-P345-50UG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

Purified Anti-PtdIns(3,4,5)P3 monoclonal antibody. Subclass: IgM Source: Mouse Applications: ELISA, Immunofluorescence

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Product Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Storage

2-8 C for up to 30 days, -20 C for greater than 30 days. Do not freeze thaw multiple times.

Featured in Publications

1) Chen, R., V. H. Kang, et al. (2002). A monoclonal antibody to visualize PtdIns(3,4,5)P(3) in cells. J Histochem Cytochem 50(5): 697-708. 2) Weiner, O. D., P. O. Neilsen, et al. (2002). A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol 4(7): 509-13. 3) Silva, A., J. A. Yunes, et al. (2008). PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. J Clin Invest 118(11): 3762-74. 4) Shearn, C. T., R. L. Smathers, et al. (2011). Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes. Mol Pharmacol 79(6): 941-52. Product keywords: PIP3, PI(3,4,5)P3, PtdIns(3,4,5)P3, IgM, anti-PIP3

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Documents

Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Antibodies & Proteins. Related: Antibody, Lipid Binding, PI(3\,4\,5)P3. Ship 1 : Shipping Temp. Ship 2: Dry Ice