Z-P400 is a goat polycolonal antibody targeting human Autotaxin (ATX). ATX, also known as ENPP2, cleaves choline from lysophosphatidylcholine forming lysophosphatidic acid (LPA), a potent mitogen that has been implicated in the pathophysiology of ovarian cancer. ATX has been demonstrated to increase cell motility, neovascularization, proliferation, and aggressiveness of tumors and is upregulated in numerous cancer lineages (non-small cell lung , glioma, mammary carcinoma, renal cell carcinoma, hepatocellular carcinoma). In addition, dysregulation of the ATX/LPA pathway is central to the pathophysiology of idiopathic pulmonary fibrosis, rheumatoid arthritis, and other inflammatory diseases.
