PIKfyve (aka PIP5K3) is an approximately 237 kDa lipid kinase enzyme. It is primarily found on early endosomes where it synthesizes PI(3 5)P2 from membrane-associated PI(3)P. Endosomal PIKfyve forms a complex with ArPIKfyve (Vac14) and Sac3 (FIG4) to regulate fusion transport and export of endosomes in the cell. PIKfyve also has protein kinase activity in the form of self-regulatory autophosphorylation.Z-RPK5 PIKfyve antibody has been validated for WB IP and ICC and has been shown to recognize human and mouse/rat isoforms. The antibody is compatible withA in vitro assays for PIKfyve activity. The antibody was generated from a fusion protein with amino acids 1 to 100 of murine PIKfyve.
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120 10 mg (H-250F)
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