Cdk 5, Cdk5, CDK5_HUMAN, Cell division protein kinase 5, Crk6, Cyclin dependent kinase 5, Cyclin-dependent kinase 5, Protein kinase CDK5 splicing, PSSALRE, Serine threonine protein kinase PSSALRE, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit.
Activated by cyclins but by p35 (CDK5R1) and p39. An important regulator of neuronal positioning during brain development. May also play a role in synaptogenesis and neurotransmission. Substrates include TAU, MAP2, NF-H and -M, Nudel, PDE6, beta-catenin, amphyphysin, dynamin I, synapsin 1, Munc-18, and NMDA receptor 2A. Plays a role in myogenesis, haematopoietic cell differentiation, spermatogenesis, insulin secretion, and lens differentiation.
