DR5 (3Q11) Rabbit Monoclonal Antibody, Unconjugated

Produktübersicht

• Artikelname: DR5 (3Q11) Rabbit Monoclonal Antibody, Unconjugated
• Artikelnummer: EKL-AMRE10151
• Hersteller Artikelnummer: AMRe10151
• Alternativnummer: EKL-AMRE10151-50UL, EKL-AMRE10151-100UL, EKL-AMRE10151-200UL
• Hersteller: EnkiLife
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IF, IHC, IP, WB
• Spezies Reaktivität: Human
• Konjugation: Unconjugated
• Alternative Synonym: Death receptor 5, TRAIL receptor 2, TRAIL-R2, CD262, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9,

Produktbeschreibung

Plays an important role in the regulation of apoptosis in various physiological systems. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Produkteigenschaften

• Klonalität: Monoclonal
• Molekulargewicht: 49kDa
• NCBI: 8795
• UniProt: O14763
• Puffer: Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
• Reinheit: Affinity purification
• Formulierung: Liquid
• Target-Kategorie: TNFRSF10B

Anwendungsbeschreibung

• Application Verdünnung: WB 1:500-1:2000,IHC 1:200-1:2000,IP 1:20-1:50,IF-P 1:200-1:2000