Frizzled 9 / CD349 (15O7) Rabbit Monoclonal Antibody, Unconjugated

Produktübersicht

• Artikelname: Frizzled 9 / CD349 (15O7) Rabbit Monoclonal Antibody, Unconjugated
• Artikelnummer: EKL-AMRE11138
• Hersteller Artikelnummer: AMRe11138
• Alternativnummer: EKL-AMRE11138-50UL, EKL-AMRE11138-100UL, EKL-AMRE11138-200UL
• Hersteller: EnkiLife
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human, Mouse, Rat
• Konjugation: Unconjugated
• Alternative Synonym: CD349, frizzled-9, Fz-9, FZD3, FzE6

Produktbeschreibung

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta- catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity).

Produkteigenschaften

• Klonalität: Monoclonal
• Molekulargewicht: 64kDa
• NCBI: 8326
• UniProt: O00144
• Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Reinheit: Affinity purification
• Formulierung: Liquid
• Target-Kategorie: FZD9

Anwendungsbeschreibung

• Application Verdünnung: WB 1:1000-1:5000