GABARAP (11T4) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE11243
Produktübersicht
Artikelname:
GABARAP (11T4) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE11243
Hersteller Artikelnummer:
AMRe11243
Alternativnummer:
EKL-AMRE11243-50UL, EKL-AMRE11243-100UL, EKL-AMRE11243-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC, WB
Spezies Reaktivität:
Human, Rat
Konjugation:
Unconjugated
Alternative Synonym:
GABARAP, GABARAPL1, GABARAPL2,
Produktbeschreibung
GABARAP is cleaved at its carboxyl terminus, which leads to conjugation by either of the phospholipids phosphatidylethanolamine or phosphatidylserine. This processing converts GABARAP from a type I to a type II membrane bound form involved in autophagosome biogenesis. Processing of GABARAP involves cleavage by Atg4 family members followed by conjugation by the E1 and E2 like enzymes Atg7 and Atg3. Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:9892355). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed: 15169837, PubMed: 20562859, PubMed: 22948227). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed: 31006538). Also required for the local activition of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction (PubMed: 25684205). Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (PubMed: 25684205). Involved in apoptosis (PubMed: 15977068).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
14kDa
NCBI:
11337
UniProt:
O95166
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
GABARAP
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000,IHC 1:100-1:200
