GATA4 (6U13) Rabbit Monoclonal Antibody, Unconjugated

Produktübersicht

• Artikelname: GATA4 (6U13) Rabbit Monoclonal Antibody, Unconjugated
• Artikelnummer: EKL-AMRE11313
• Hersteller Artikelnummer: AMRe11313
• Alternativnummer: EKL-AMRE11313-50UL, EKL-AMRE11313-100UL, EKL-AMRE11313-200UL
• Hersteller: EnkiLife
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: FC, ICC, IHC, WB
• Spezies Reaktivität: Human, Mouse, Rat
• Konjugation: Unconjugated
• Alternative Synonym: ASD2, GATA 4, GATA binding protein 4, gata4, Transcription factor GATA 4, VSD1,

Produktbeschreibung

Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Transcriptional activator that binds to the consensus sequence 5-AGATAG-3 and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735).

Produkteigenschaften

• Klonalität: Monoclonal
• Molekulargewicht: 45kDa
• NCBI: 2626
• UniProt: P43694
• Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Reinheit: Affinity purification
• Formulierung: Liquid
• Target-Kategorie: GATA4

Anwendungsbeschreibung

• Application Verdünnung: WB 1:1000-1:5000,IHC 1:50-1:200,ICC/IF 1:100-1:200,FC 1:50-1:200