Interferon gamma (16O15) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE12684
Produktübersicht
Artikelname:
Interferon gamma (16O15) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE12684
Hersteller Artikelnummer:
AMRe12684
Alternativnummer:
EKL-AMRE12684-50UL, EKL-AMRE12684-100UL, EKL-AMRE12684-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, IHC
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Alternative Synonym:
IFG, IFI, IFN gamma, IFN, immune, IFN-gamma, IFNG, Immune interferon, Interferon gamma,
Produktbeschreibung
Interferon (IFN)-gamma is an antiviral and antiparasitic agent produced by CD4+/CD8+ lymphocytes and natural killer cells that undergo activation by antigens, mitogens or alloantigens. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:16914093, PubMed: 8666937). Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation (PubMed: 8349687). Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription (PubMed: 16914093). Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits (PubMed: 8666937). In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading (PubMed: 8163024). Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference (PubMed: 11112687). Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (PubMed: 7729559). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
19kDa
NCBI:
3458
UniProt:
P01579
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
IFNG
Anwendungsbeschreibung
Application Verdünnung:
IHC 1:200-1:500,IF-P 1:200-1:500
