Interferon Receptor alpha (15I18) Rabbit Monoclonal Antibody, Unconjugated

Produktübersicht

• Artikelname: Interferon Receptor alpha (15I18) Rabbit Monoclonal Antibody, Unconjugated
• Artikelnummer: EKL-AMRE12685
• Hersteller Artikelnummer: AMRe12685
• Alternativnummer: EKL-AMRE12685-50UL, EKL-AMRE12685-100UL, EKL-AMRE12685-200UL
• Hersteller: EnkiLife
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human
• Konjugation: Unconjugated
• Alternative Synonym: AVP, IFN alpha REC, IFNAR1, IFNBR, IFRC, interferon (alpha beta and omega) receptor 1,

Produktbeschreibung

Interferon Receptor alpha (IFN-a R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986, PubMed:32972995). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

Produkteigenschaften

• Klonalität: Monoclonal
• Molekulargewicht: 64kDa
• NCBI: 3454
• UniProt: P17181
• Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Reinheit: Affinity purification
• Formulierung: Liquid
• Target-Kategorie: IFNAR1

Anwendungsbeschreibung

• Application Verdünnung: WB 1:1000-1:5000