Mitofusin 2 (8H7) Rabbit Monoclonal Antibody, Unconjugated

Produktübersicht

• Artikelname: Mitofusin 2 (8H7) Rabbit Monoclonal Antibody, Unconjugated
• Artikelnummer: EKL-AMRE13921
• Hersteller Artikelnummer: AMRe13921
• Alternativnummer: EKL-AMRE13921-50UL, EKL-AMRE13921-100UL, EKL-AMRE13921-200UL
• Hersteller: EnkiLife
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ICC, IHC, WB
• Spezies Reaktivität: Human, Mouse, Rat
• Konjugation: Unconjugated
• Alternative Synonym: CMT2A2, CMT2A, CPRP1, MFN2, Hyperplasia suppressor, MARF, Mitofusin 2, HSG, Mitofusin-2,

Produktbeschreibung

Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:26214738, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity).

Produkteigenschaften

• Klonalität: Monoclonal
• Molekulargewicht: 86kDa
• NCBI: 9927
• UniProt: O95140
• Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Reinheit: Affinity purification
• Formulierung: Liquid
• Target-Kategorie: MFN2

Anwendungsbeschreibung

• Application Verdünnung: WB 1:1000-1:5000,IHC 1:50-1:100,ICC/IF 1:100-1:200