MRP2 (11R9) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE14101
Produktübersicht
Artikelname:
MRP2 (11R9) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE14101
Hersteller Artikelnummer:
AMRe14101
Alternativnummer:
EKL-AMRE14101-50UL, EKL-AMRE14101-100UL, EKL-AMRE14101-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FC, ICC, IHC, WB
Spezies Reaktivität:
Human, Mouse
Konjugation:
Unconjugated
Alternative Synonym:
ABC30, abcC2, CMOAT1, cMRP,
Produktbeschreibung
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)- conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed: 10421658, PubMed: 11500505, PubMed: 16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed: 10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17- glucosiduronic acid and leukotriene C4 (PubMed: 11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed: 16332456). Transport various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed: 10220572, PubMed: 11500505, PubMed: 12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed: 10220572, PubMed: 11500505).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
174kDa
NCBI:
1244
UniProt:
Q92887
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
ABCC2
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000,IHC 1:1000-1:10000,ICC/IF 1:100-1:200,FC 1:50-1:100
