UBE3A (15N18) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE19533
Produktübersicht
Artikelname:
UBE3A (15N18) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE19533
Hersteller Artikelnummer:
AMRe19533
Alternativnummer:
EKL-AMRE19533-50UL, EKL-AMRE19533-100UL, EKL-AMRE19533-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
Ubiquitin-protein ligase E3A, UBE3A, E6AP, EPVE6AP, HPVE6A,
Produktbeschreibung
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed: 16772533, PubMed: 19204938, PubMed: 19233847, PubMed: 19325566, PubMed: 19591933, PubMed: 22645313, PubMed: 24273172, PubMed: 24728990). Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed: 10373495, PubMed: 19204938, PubMed: 19325566, PubMed: 19591933, PubMed: 22645313, PubMed: 24728990). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed: 19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed: 24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed: 16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed: 16772533).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
101kDa
NCBI:
7337
UniProt:
Q05086
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
UBE3A
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000
