Cell localization:Cytoplasmic.This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellµLar protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellµLar interactions. Expression of this gene is known to be regµLated by several microRNAs, and overexpression of this gene may play a role in the metastasis of mµLtiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkins lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011],
