Wolf Hirschhorn syndrome candidate 1 like 1, WHSC1L1, NSD3, pp14328, Histone-lysine N-methyltransferase NSD3, Protein whistle,,NSD3
Histone methyltransferase. Preferentially dimethylates Lys-4 and Lys-27 of histone H3 forming H3K2me2 and H3K27me2. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation, while Lys-27 is a mark for transcriptional repression.