CANDF7, ISGF 3 , Signal transducer and activator of transcription 1, 91kDa, Signal transducer and activator of transcription 1-alpha/beta, Stat1, STAT91, Transcription factor ISGF-3 components p91/p84,,STAT1
Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus.
