ADMFD, AIF4, AIP4, Atrophin 1 interacting protein 4, Itchy homolog E3 ubiquitin protein ligase, NAPP1, NFE2 associated polypeptide 1, Ubiquitin protein ligase ITCH,,ITCH
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.