Histone H2B type 1-H, Histone H2B.j, H2B/j, HIST1H2BH, H2BFJ,,Crotonyl-Histone H2B type 2E (K12)
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.