LIM Kinase 2 Rabbit Polyclonal Antibody, Unconjugated

Produktübersicht

• Artikelname: LIM Kinase 2 Rabbit Polyclonal Antibody, Unconjugated
• Artikelnummer: EKL-APRAB00460
• Hersteller Artikelnummer: APRab00460
• Alternativnummer: EKL-APRAB00460-20UL, EKL-APRAB00460-50UL, EKL-APRAB00460-100UL, EKL-APRAB00460-200UL
• Hersteller: EnkiLife
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ICC, IHC, WB
• Spezies Reaktivität: Human, Mouse, Rat
• Konjugation: Unconjugated
• Alternative Synonym: LIM domain kinase 2

Produktbeschreibung

Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways, phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865).

Produkteigenschaften

• Klonalität: Polyclonal
• Molekulargewicht: Calculated MW: 72 kDa, Observed MW: 72 kDa
• NCBI: 3985
• UniProt: P53671
• Puffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
• Reinheit: Affinity Purification
• Formulierung: Liquid
• Target-Kategorie: LIMK2

Anwendungsbeschreibung

• Application Verdünnung: WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:100-1:200