CDK5RAP1, C20orf34, CGI-05, HSPC167, CDK5 regulatory subunit-associated protein 1, CDK5 activator-binding protein C42
This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013],cofactor:Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.,function:Specifically inhibits CDK5 activation by CDK5R1.,sequence caution:Translated as Glu.,similarity:Belongs to the methylthiotransferase family. MiaB subfamily.,similarity:Contains 1 MTTase N-terminal domain.,similarity:Contains 1 TRAM domain.,subunit:Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Forms a complex with CDK5R1 and CDK5.,tissue specificity:Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
