TSTA3, SDR4E1, GDP-L-fucose synthase, GDP-4-keto-6-deoxy-D-mannose-3, 5-epimerase-4-reductase, Protein FX, Red cell NADP(H)-binding protein, Short-chain dehydrogenase/reductase family 4E member 1
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008],catalytic activity:GDP-L-fucose + NADP(+) = GDP-4-dehydro-6-deoxy-D-mannose + NADPH.,function:Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.,pathway:Nucleotide-sugar biosynthesis, GDP-L-fucose biosynthesis via de novo pathway, GDP-L-fucose from GDP-D-mannose: step 2/2.,similarity:Belongs to the fucose synthetase family.,subunit:Homodimer.,
