This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010],catalytic activity:L-histidine = histamine + CO(2).,cofactor:Pyridoxal phosphate.,pathway:Amine and polyamine biosynthesis, histamine biosynthesis, histamine from L-histidine: step 1/1.,similarity:Belongs to the group II decarboxylase family.,subunit:Homodimer.,
