Keratin, type II cytoskeletal 1b (Cytokeratin-1B,CK-1B,Keratin-77,K77,Type-II keratin Kb39)
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009],miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic, 40-55 kDa) and II (neutral to basic, 56-70 kDa).,PTM:Undergoes deimination of some arginine residues (citrullination).,similarity:Belongs to the intermediate filament family.,tissue specificity:Expressed exclusively in skin.,
