MARCH3, RNF173, E3 ubiquitin-protein ligase MARCH3, Membrane-associated RING finger protein 3, Membrane-associated RING-CH protein III, MARCH-III, RING finger protein 173
This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013],domain:The RING-CH-type zinc finger domain is required for E3 ligase activity.,function:E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification, protein ubiquitination.,similarity:Contains 1 RING-CH-type zinc finger.,subunit:Interacts with MARCH2 and STX6.,
