ANO7, NGEP, PCANAP5, TMEM16G, Anoctamin-7, Dresden transmembrane protein of the prostate, D-TMPP, IPCA-5, New gene expressed in prostate, Prostate cancer-associated protein 5, Transmembrane protein 16G
This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011],caution:It is uncertain whether Met-1 or Met-55 is the initiator.,function:May act as a calcium-activated chloride channel. May play a role in cell-cell interactions.,induction:Up-regulated by androgen.,similarity:Belongs to the anoctamin family.,subcellular location:Concentrates at sites of cell-cell contact.,tissue specificity:Specifically expressed in epithelial cells of the prostate (at protein level).,
