The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],caution:PubMed:12189208 experiments have been carried out partly in rat and partly in human.,domain:Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG.,function:Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.,similarity:Belongs to the DNA2/NAM7 helicase family.,similarity:Contains 1 C2H2-type zinc finger.,subunit:Interacts with PPARA, ESR1, THRB and RXRA. It is probably part of the peroxisome proliferator activated receptor alpha interacting complex (PRIC). Also interacts with the DNA-binding domain of PPARG.,tissue specificity:Expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver, kidney, lung, peripheral blood and placenta.,
