PTX3, TNFAIP5, TSG14, Pentraxin-related protein PTX3, Pentaxin-related protein PTX3, Tumor necrosis factor alpha-induced protein 5, TNF alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14
This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016],function:Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.,induction:By interleukin-1 beta and TNF-alpha.,PTM:Glycosylated.,similarity:Contains 1 pentaxin domain.,subunit:Homooctamer, disulfide-linked. Binds to C1q.,
