This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011],function:Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins, such as ERBB3.,pathway:Protein modification, protein ubiquitination.,PTM:Autoubiquitinated.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SIAH-type zinc finger.,subunit:Interacts with USP8 and ERBB3.,tissue specificity:Detected in ovary, testis and prostate.,
