Protein S100-A7 (Psoriasin,S100 calcium-binding protein A7)
S100 calcium binding protein A7(S100A7) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014],mass spectrometry: PubMed:8526920,similarity:Belongs to the S-101 family.,similarity:Contains 2 EF-hand domains.,subcellular location:Secreted by a non-classical secretory pathway.,subunit:Interacts with RANBP9.,tissue specificity:Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.,
