SUMO1 (UBL1, MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004],domain:The N-terminus is necessary and sufficient for nuclear envelope targeting.,function:Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.,PTM:Polyubiquitinated, which leads to proteasomal degradation.,similarity:Belongs to the peptidase C48 family.,subcellular location:Shuttles between cytoplasm and nucleus.,subunit:Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus.,
