PRSS3, PRSS4, TRY3, TRY4, Trypsin-3, Brain trypsinogen, Mesotrypsinogen, Serine protease 3, Serine protease 4, Trypsin III, Trypsin IV
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010],catalytic activity:Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.,cofactor:Binds 1 calcium ion per subunit.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Pancreas and brain.,
