Recombinant Human DR6 (C-6His)

Produktübersicht

• Artikelname: Recombinant Human DR6 (C-6His)
• Artikelnummer: EKL-PHH0340
• Hersteller Artikelnummer: PHH0340
• Alternativnummer: EKL-PHH0340-10UG,EKL-PHH0340-50UG,EKL-PHH0340-500UG
• Hersteller: EnkiLife
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Alternative Synonym: Tumor Necrosis Factor Receptor Superfamily Member 21, Death Receptor 6, CD358, TNFRSF21, DR6

Produktbeschreibung

Tumor Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. DR6 may activate NF-kappa-B and JNK to promote apoptosis and T-cell differentiation. In addition, DR6 binds with N-APP, which is released by the deprivation of Trophic-factor. It triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). DR6 is also expressed on the tumor cell lines and can be induced by TNF-alpha.

Produkteigenschaften

• Molekulargewicht: 34.62 KDa
• NCBI: 75509
• Reinheit: Greater than 95% as determined by reducing SDS-PAGE

Anwendungsbeschreibung

• Anwendungsbeschreibung: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100µg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.