Recombinant Human LDL R (C-6His)

Produktübersicht

• Artikelname: Recombinant Human LDL R (C-6His)
• Artikelnummer: EKL-PHH1070
• Hersteller Artikelnummer: PHH1070
• Alternativnummer: EKL-PHH1070-10UG,EKL-PHH1070-50UG,EKL-PHH1070-500UG
• Hersteller: EnkiLife
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Alternative Synonym: Low-Density Lipoprotein Receptor, LDL Receptor, LDLR

Produktbeschreibung

Low-Density Lipoprotein Receptor (LDLR) is a transmembrane glycoprotein that plays a critical role in cholesterol homeostasis. LDLR mediates blood cholesterol level by interacting with lipoprotein particles like LDL and VLDL. The extracellular domain of LDLR contains LDL receptor type A (ligand-binding) modules (LA repeats), epidermal growth factor-like modules, and LY repeats containing the YWTD consensus motif that are important in binding and releasing of ApoB-100 and ApoE in lipoprotein particles. The C terminal domain of LDLR inside the cell is required for the receptor internalization. Loss of function mutations in the LDLR gene causes Familial Hypercholesterolemia (FH).

Produkteigenschaften

• Molekulargewicht: 86.56 KDa
• NCBI: 01130
• Reinheit: Greater than 95% as determined by reducing SDS-PAGE

Anwendungsbeschreibung

• Anwendungsbeschreibung: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100µg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.