Recombinant Human CD161 (N-Fc)

Produktübersicht

• Artikelname: Recombinant Human CD161 (N-Fc)
• Artikelnummer: EKL-PHH2377
• Hersteller Artikelnummer: PHH2377
• Alternativnummer: EKL-PHH2377-10UG,EKL-PHH2377-50UG,EKL-PHH2377-500UG
• Hersteller: EnkiLife
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Alternative Synonym: Killer cell lectin-like receptor subfamily B member 1,KLRB1,CLEC5B, NKRP1A,CD161,Natural killer cell surface protein P1A,NKR-P1A,HNKR-P1a,C-type lectin domain family 5 member B,KLRB1

Produktbeschreibung

Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

Produkteigenschaften

• Molekulargewicht: 45 KDa
• NCBI: 12918
• Reinheit: Greater than 95% as determined by reducing SDS-PAGE

Anwendungsbeschreibung

• Anwendungsbeschreibung: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100µg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.