Recombinant Human Latent TGF Beta-1&GARP Complex Protein (N-6His, C-3*Strep)

Produktübersicht

• Artikelname: Recombinant Human Latent TGF Beta-1&GARP Complex Protein (N-6His, C-3*Strep)
• Artikelnummer: EKL-PHH2379
• Hersteller Artikelnummer: PHH2379
• Alternativnummer: EKL-PHH2379-10UG,EKL-PHH2379-50UG,EKL-PHH2379-500UG
• Hersteller: EnkiLife
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Alternative Synonym: TGF Beta-1&GARP

Produktbeschreibung

Transforming Growth Factor beta-1 (TGFbeta-1) is a secreted protein which belongs to the TGF-beta family. TGFbeta-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFbeta-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFbeta-1 peptide. Leucine Rich Repeat Containing 32 (LRRC32), also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T(regs). LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naive T cell proliferation.

Produkteigenschaften

• Molekulargewicht: 42.1&71.0 KDa
• NCBI: 01137
• Reinheit: Greater than 95% as determined by reducing SDS-PAGE

Anwendungsbeschreibung

• Anwendungsbeschreibung: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100µg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.