Hepatitis B virus (HBV) infection leads to a wide spectrum of liver diseases ranging from acute to chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). The hallmark of chronic HBV infection is the presence of hepatitis B surface antigen (HBsAg) positivity for 6 months. Many studies in different clinical settings of HBV infection have suggested serum HBsAg quantitation as a surrogate marker of HBV DNA levels. Many studies in different clinical settings of HBV infection have suggested serum HBsAg quantitation as a surrogate marker of HBV DNA levels.
