Recombinant Mouse DR6 (C-Fc-6His), Human

Produktübersicht

• Artikelname: Recombinant Mouse DR6 (C-Fc-6His), Human
• Artikelnummer: EKL-PHM0341
• Hersteller Artikelnummer: PHM0341
• Alternativnummer: EKL-PHM0341-10UG,EKL-PHM0341-50UG,EKL-PHM0341-500UG
• Hersteller: EnkiLife
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Mouse
• Alternative Synonym: Tumor necrosis factor receptor superfamily member 21,Death receptor 6,Tnfrsf21,CD358,BM-018,DR6

Produktbeschreibung

Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

Produkteigenschaften

• Molekulargewicht: 64.7 KDa
• NCBI: 9
• Reinheit: Greater than 95% as determined by reducing SDS-PAGE

Anwendungsbeschreibung

• Anwendungsbeschreibung: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100µg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.