Selective inhibitor of MLC kinase (Ki=3.8 µM). Inhibits insulin-stimulated 2-deoxyglucose transport and PP-1 activation in adipocytes, possibly via an effect on MAP kinase or its activation. Useful PKB inhibitor (IC50=10-50 µM). Also known to inhibit PKA
Molekulargewicht:
361.3
Reinheit:
98% (TLC)
CAS Nummer:
[105637-50-1]
Formel:
C15H17N2O2SCl . HCl
Target-Kategorie:
MLCK, Akt, PKA, S6 kinase
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