Leukocytes of a patient suffering from LGL Type Leukaemia.
CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.
Klonalität:
Monoclonal
Konzentration:
1 mg/ml
Klon-Bezeichnung:
[MEM-85]
Isotyp:
Mouse IgG2b
Puffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Lagerung:
2°C to 8°C
Target-Kategorie:
CD44
Antibody Type:
Monoclonal Antibody
Anwendungsbeschreibung:
Flow cytometry: Recommended dilution: 2-6 µg/ml. Western blotting: Recommended dilution: 2 µg/ml, 60 min on vertical incubator, positive control: Kg-1a human leukemia cell lysate, non-reducing conditions.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
