Bacterially expressed recombinant fragment of human Lyn (aa 8 - 238).
Lyn is a Src-family protein tyrosine kinase that is predominantly expressed in hematopoietic cells. It is associated with a number of cell surface receptors including the B cell antigen receptor (BCR) and Fc receptors. Upon their triggering, Lyn phosphorylates subunits of these receptors in a cholesterol-dependent manner, utilizing the plasma membrane lipid raft system. The phosphorylated intracellular domains of the receptors are accessible for cytoplasmic Syk tyrosine kinase, which is activated by Lyn-mediated phosphorylation and which transduces the signal to downstream adaptors. Lyn is abnormally distributed in acute myeloid leukemia cells and seems to be a novel pharmacologic target of this disease.
Klonalität:
Monoclonal
Konzentration:
1 mg/ml
Klon-Bezeichnung:
[LYN-01]
Isotyp:
Mouse IgG1
Puffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Lagerung:
2°C to 8°C
Target-Kategorie:
LYN
Antibody Type:
Monoclonal Antibody
Anwendungsbeschreibung:
Western blotting: Recommended dilution: 1-2 µg/ml.
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