Anti-Hu Granzyme A Purified, Clone: [CB9], Monoclonal
Artikelnummer:
EXB-11-883-C100
Hersteller Artikelnummer:
11-883-C100
Alternativnummer:
EXB-11-883-C100
Hersteller:
EXBIO
Kategorie:
Antikörper
Applikation:
FC, ICC, IP
Spezies Reaktivität:
Human
Immunogen:
Full length human granzyme A
Granzyme A is a serine protease expressed in the cytoplasmic granules of T cells and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Similarly to granzyme B, granzyme A acts to destroy the target cells by proteolysis of their particular components. In case of granzyme A the targets are e.g. APEX1 (it destroys its oxidative repair activity), and nucleosome assembly protein SET (it disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA).
Klonalität:
Monoclonal
Konzentration:
1 mg/ml
Klon-Bezeichnung:
[CB9]
Isotyp:
Mouse IgG1 kappa
Puffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
