Anti-Hu CD49d FITC, Clone: [9F10], Monoclonal

Produktübersicht

• Artikelname: Anti-Hu CD49d FITC, Clone: [9F10], Monoclonal
• Artikelnummer: EXB-1F-171-T100
• Hersteller Artikelnummer: 1F-171-T100
• Alternativnummer: EXB-1F-171-T100
• Hersteller: EXBIO
• Kategorie: Antikörper
• Applikation: FC
• Spezies Reaktivität: Bovine, Canine, Equine, Feline, Human, Primate, Sheep
• Konjugation: FITC

Produktbeschreibung

CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [9F10]
• Isotyp: Mouse IgG1 kappa
• Puffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Lagerung: 2°C to 8°C
• Target-Kategorie: CD49d
• Antibody Type: Monoclonal Antibody

Anwendungsbeschreibung

• Application Verdünnung: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
• Anwendungsbeschreibung: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.