Anti-Hu CD18 FITC, Clone: [MEM-48], Monoclonal

Produktübersicht

• Artikelname: Anti-Hu CD18 FITC, Clone: [MEM-48], Monoclonal
• Artikelnummer: EXB-1F-216-T100
• Hersteller Artikelnummer: 1F-216-T100
• Alternativnummer: EXB-1F-216-T100
• Hersteller: EXBIO
• Kategorie: Antikörper
• Applikation: FC
• Spezies Reaktivität: Human
• Immunogen: Leukocytes of a patient suffering from a LGL-type leukemia.
• Konjugation: FITC

Produktbeschreibung

CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [MEM-48]
• Isotyp: Mouse IgG1
• Puffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Lagerung: 2°C to 8°C
• Target-Kategorie: CD18
• Antibody Type: Monoclonal Antibody

Anwendungsbeschreibung

• Application Verdünnung: Flow cytometry: The reagent is designed for analysis of human blood cells using 20 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
• Anwendungsbeschreibung: Flow cytometry: The reagent is designed for analysis of human blood cells using 20 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.