Anti-Hu CD22 PerCP-Cy5.5, Clone: [S-HCL-1], Monoclonal

Produktübersicht

• Artikelname: Anti-Hu CD22 PerCP-Cy5.5, Clone: [S-HCL-1], Monoclonal
• Artikelnummer: EXB-T9-175-T100
• Hersteller Artikelnummer: T9-175-T100
• Alternativnummer: EXB-T9-175-T100
• Hersteller: EXBIO
• Kategorie: Antikörper
• Applikation: FC
• Spezies Reaktivität: Human
• Immunogen: Whole hairy cell leukemia cells and membrane preparation
• Konjugation: PerCP/Cy5.5

Produktbeschreibung

CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [S-HCL-1]
• Isotyp: Mouse IgG2b kappa
• Puffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Lagerung: 2°C to 8°C
• Target-Kategorie: CD22
• Antibody Type: Monoclonal Antibody

Anwendungsbeschreibung

• Application Verdünnung: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
• Anwendungsbeschreibung: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. Extracellular and intracellular staining.