98% by TLC [60% ethyl acetate in hexane, Rf = 0.36] NMR conforms
Formulierung:
Pale yellow solid
CAS Nummer:
[269390-77-4]
Formel:
C20H16F3N3O
Anwendungsbeschreibung:
Inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-ß, cKit, and CSF-1R are also inhibited at higher concentrations (IC50s 640 nM, 236 nM and 380 nM respectively). Screening studies have shown no inhibitory activity against a range of other kinases. X-Ray crystallography has shown that AAL-993 binds to the catalytic domain of VEGFR-2 when the protein is in an inactive conformation. Cell permeable, active in vivo and in whole animal studies.
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