AG-490, CAS [[133550-30-8]]

Produktübersicht

• Artikelname: AG-490, CAS [[133550-30-8]]
• Artikelnummer: FBM-10-1091
• Hersteller Artikelnummer: 10-1091
• Alternativnummer: FBM-10-1091-5MG,FBM-10-1091-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

JAK-2 inhibitor

Produkteigenschaften

• Molekulargewicht: 294.31
• Reinheit: 98% by TLC [ 10% methanol in methylene chloride, Rf = 0.50] NMR Conforms
• Formulierung: Tan solid
• CAS Nummer: [133550-30-8]
• Formel: C17H14N2O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock3. A useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes4.