Zileuton, CAS [[111406-87-2]]

Produktübersicht

• Artikelname: Zileuton, CAS [[111406-87-2]]
• Artikelnummer: FBM-10-1098
• Hersteller Artikelnummer: 10-1098
• Alternativnummer: FBM-10-1098-10MG,FBM-10-1098-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

5-LO inhibitor

Produkteigenschaften

• Molekulargewicht: 236.29
• Reinheit: >98%, NMR (Conforms)
• Formulierung: white solid
• CAS Nummer: [111406-87-2]
• Formel: C11H12N2O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Zileuton is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO).1 It also inhibited leukotriene B4 biosynthesis (IC50s = 400nM rat PMNL, 400nM human PMNL and 900nM human whole blood).1 Zileuton suppressed prostaglandin biosynthesis via interference with arachidonic acid release in macrophages independent of 5-LO inhibition (IC50 = 13 µM PGE2 inhibition in LPS-stimulated whole blood).2 Zileuton was approved by the FDA in 1997 for the treatment of asthma (ZYFLO).