Chemical Name: 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acid. Alternate Names: ATRA, Tretinoin
Retinoid RAR agonist
Molekulargewicht:
300.44
Reinheit:
98% NMR Conforms
Formulierung:
Yellow solid
CAS Nummer:
[302-79-4]
Formel:
C20H28O2
Anwendungsbeschreibung:
All-trans-Retinoic acid (ATRA, a metabolite of Vitamin A) is an endogenous ligand for the retinoic acid receptor (RAR). The binding of retinoic acid to the RAR and retinoid X (RXR) heterodimer causes conformation changes in RAR that affects the binding of other proteins that regulate the growth and differentiation of a variety of both normal and malignant cells.1 ATRA promotes differentiation of embryonic stem cells (ESCs) into a variety of cell types in vitro.2-4
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